Gold antimicrobial activity

Exploration of new complexes with useful antimicrobial activities has stimulated extensive development of synthetic chemistry of silver(I) complexes. The incorporation of novel ligands can moderate the physical and chemical properties of complexes. For example, the bis(diphosphine)silver(I) complexes (which are analogues of the bis(diphosphine)gold(l) complexes with promising antitumor activity compromised by their antimitochondrial activity) were examined for antitumor and antimicrobial activity by... 

An examination of an acetone extract of 5. denticulata, collected from the coast of New South Wales, has resulted in the identification of two isomeric polypropionates denticulatin A [136] and denticulatin B [137](108). No antimicrobial activity was found associated with these denticulatins. However, both showed ichthyotoxicity toward gold fish (108). 

Despite the limited number of examples reported in the literature concerning the antimicrobial activity of gold-NHC systems and the numerous studies of silver species, no research on this subject has been reported with copper analogs. 

Figure 15.5 Early NHC-gold(i) complexes from (Jetinkaya with in vitro antimicrobial activity.

Perni S, Picdrillo C, Pratten J et al. (2009) The antimicrobial properties of light-activated polymers containing methylene blue and gold nanoparticles. Biomaterials 30 89-93... 

A method for producing an improved antimicrobial material is disclosed whereby a soft, diy, iodine/acetalised polyviityl alcohol complex sponge material is produced which has a pleasing yellow-gold colouration indicating activation of the antimicrobial elements in the complex. 

A gold complex auranofin has been developed for the treatment of rheumatoid arthritis. This is a typical linear two-coordinate complex of gold , with soft S and P donors to match the soft metal ion (Figure 9.4). The bulky ligands here promote compatibility in the bio-environment, and activity is influenced by the substituents on the RS and R3P ligands. Gold complexes have also been examined for antimicrobial, antimalarial and anti HIV (human immunodeficiency virus) activity. A copper(II) complex (Figure 9.4) is effective as a competitive inhibitor of HIV-1. 

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