Gnididione

Jacobi and coworkers used an oxy-Cope/Diels-Alder sequence to synthesize the tumor inhibitor gnididione (4-234) [80]. A similar sequence was also used by Kraus and coworkers for the synthesis of 11-deoxydaunomycinone (4-235) [81]. 

A sequential Cope/Diels-Alder/retro-Diels-Alder reaction is the key step in the synthesis of furanosesquiterpene gnididione (3), isolated from the antileukaemic fractions of Gnidia latifo-lia. The reaction strongly depends on the relative configuration at C-8, as the alternative diastereomer reacts at a faster rate with acetylenic tt-bond participation970. 

Germanyl trisulfide, 163 Glyceraldehyde acetonide, 105 Glyoxylate, 125 cycloaddition, 95-100 Gnididione, 310... 

Synthesis of Evodone Synthesis of Ligularone and Petasalbine Synthesis of Paniculide-A Synthesis of Gnididione Synthesis of Norsecurinine Synthetic Approach to Geigerin Synthesis of Stemoamide Thiofurans and Amidofurans... 

The furanosesquiterpene gnididione was isolated from Gnidia latifolia in the course of searches for plant-based tumor inhibitors. Racemic gnididione and isognididione were synthesized by employing a chemoselective sequential intramolecular oxy-Cope Diels-Alder approach. Oxazole-aldehyde 181 was available... 

Dimethyl-2//-1 -benzopyran-6-yl)-2-propenoic acid Me ester, in D-70372 Gnididione, G-60030 Heritol, H-60028... 

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