Glycyl-L-glutamic acid

The binding of glycyl-L-tyrosine in the active site pocket of carboxypeptidase A is illustrated in Fig. 15. Tyrosine-248 and glutamic acid-270 are believed to participate in the catalytic reaction and represent the acidic and basic groups, respectively, involved in the bell-shaped pK-rate profile. In the bond-cleavage reaction, the carboxyl group of Glu-270 may act by a nucleophilic attack on the carbonyl group while Tyr-248... 

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