Glycosylphosphatidylinositol role

Proximal tubular epithelial cells are richly endowed with the zinc metalloenzyme carbonic anhydrase, which is fonnd in the luminal and basolateral membranes (type IV carbonic anhydrase, an enzyme tethered to the membrane by a glycosylphosphatidylinositol linkage), as well as in the cytoplasm (type 11 carbonic anhydrase). Carbonic anhydrase plays a key role in NaHCOj reabsorption and acid secretion. 

Saifuddin M, Parker CJ, Peeples ME, Gorny MK, Zolla-Pazner S, Ghassemi M, Rooney lA, Atkinson JP, Spear GT (1995) Role of virion-associated glycosylphosphatidylinositol-linked proteins CD55 and CD59 in complement resistance of cell line-derived and primary isolates of HIV-1. J Exp Med 182 501-509... 

Walton, K. A., Hsieh, X., Gharavi, N., Wang, S., Wang, G., Yeh, M., Cole, A. L., and Berliner, J. A. 2003b. Receptors involved in the oxidized l-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein. 278, 29661-6. 

Berliner, J. A., Receptors involved in the oxidized l-palmitoyl-2-arachidonoyl-sw-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein, 2003,... 

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