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Glycosylation, chemical chemoselective

C-terminal peptide tiiioesters are used extensively in synthetic protein chemistry, especially for native chemical ligation (NCL) and other chemoselective reactions, which has inspired a search for robust synthetic strategies. Initially, peptide thioesters were mainly prepared using solid-phase peptide synthesis with amino acids N -protected with Boc (Boc-SPPS) [1-3], see Chapter 4. However, this technique requires specialized equipment for handling of hydrofluoric acid (HP) for release of the peptide from the resin, and it is therefore currently not used in many laboratories. Furthermore, the HP treatment is incompatible with many post-translational modiflcations such as glycosylations or phosphorylations [4]. Boc-SPPS is described thoroughly in Chapter 4. [Pg.119]

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See also in sourсe #XX -- [ Pg.87 , Pg.88 , Pg.115 , Pg.116 , Pg.117 , Pg.157 , Pg.158 , Pg.159 , Pg.160 , Pg.161 , Pg.162 , Pg.163 , Pg.164 , Pg.165 , Pg.166 , Pg.167 , Pg.168 , Pg.169 ]



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Chemical glycosylations

Chemoselective

Chemoselective glycosylation

Chemoselective glycosylations

Chemoselectivity

Glycosylation, chemical

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