Glycosylation and Development

Since the first examples of lower and upper rim glycocalixarenes were obtained in 1994 by Marra el al.,106 employing the Mitsunobu reaction or copper(II)-catalyzed glycosylation, the development of efficient synthetic methodologies has allowed the emergence of several examples of ()-, N-, or C-glycosyl calix arenes, and these have recently been reviewed (101-106, Fig. 8).107,10X... 

Thus, it is of interest to generate oligosaccharides of the type C-B-A in 56, all of which are linked inter-glycosidically by a-(1->4)-bonds. We have previously synthesized various derivatives of the terminal C-B disaccharides employing the Perrier glycosylation approach (59. 60). At that same time we could combine the azide functionalization of glycals (61) with the N-iodosuccin-imide method (1 ) and develop a general approach to 3-... 

Growth and differentiation. The exact structures of the oligosaccharides and polysaccharides of cell surfaces vary not only with cell and tissue type but also with the position of a cell and with time. Actions of numerous glycosyl transferases alter these saccharide groups as an organism grows and develops. 

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