Glycoside conjugates

The glycosidic conjugates 88 were prepared by reaction of 3-hydroxymethylpurpurin-l 8-iV-hcxylimidc-l 7-propionic ester 87 with the... 

Coward L, Barnes NC, Setchell KDR, Barnes S. (1993) Genistein, daidzein and their P-glycoside conjugates Antitumor and isoflavones in soybean foods from American and Asian diets. J Agric Food Chem 41 1961-1967. 

Considering the large variety of glycosidic conjugates of bilirubin demonstrated in normal bile of man (F6, HIO), dog (F7), and rat (F7,... 

Table III. Chromatography of Glycosidic Conjugates and Some Ethoxylated Compounds on Silica.

In combinatorial chemistry, the development of multicomponent reactions leading to product formation is an attractive strategy because relatively complex molecules can be assembled with fewer steps and in shorter periods. For example, the Ugi multicomponent reaction involving the combination of an isocyanide, an aldehyde, an amine, and a carboxylic acid results in the synthesis of a-acyl amino amide derivatives [32]. The scope of this reaction has been explored in solid-phase synthesis and it allows the generation of a large number of compounds with relative ease. This reaction has been employed in the synthesis of a library of C-glycoside conjugated amino amides [33]. Scheme 14.14 shows that, on reaction with carboxylic acids 38, isocyanides 39, and Rink amide resin derivatized with different amino acids 40, the C-fucose aldehyde 37 results in the library synthesis of C-linked fucosyl amino acids 41 as potential mimics of sialyl Lewis. ... 

In adults, virtually all bilirubin excreted in bile is in the form of glycosidic conjugates glucuronides account for 95% of them and glucosides and xylosides constitute the remainder. Of the glucuronides, diglucuronide is the major fraction ( 90%) and monoglucuronide the minor fraction (-10%). 

Even though the number of glycoside conjugates of xenobiotics that have been synthesized so far Is limited, the methods described here are convenient both for large and small scale operations. No specific restrictions In synthesis of Isotopically labeled conjugates should be encountered due to the synthetic methods. 

NIDA specifications call for the analysis of two opiates, codeine and morphine, whose structures are shown in Figure 8.9. Both compounds are amphoteric compounds because of the phenolic hydroxyl group and the amine group. Therefore, they are easily concentrated and purified by mixed-mode sorption. The compounds are present in urine as glycoside conjugates through the phenolic hydroxyl group. Thus, they must first be hydrolyzed in acid before isolation by SPE. 

In the class of the ceramide dihexosides, two types have been isolated a ceramide in glycosidic conjugation with (a) an O-D-galacto-pyranosyl-(l — 4)-/3-D-galactopyranosyl group,85 and (b) a 4-0-/3-D-galactopyranosyl-j8-D-glucopyranosyl residue.88... 

Recognition of the presence of glycosidically-conjugated flavor precursors in fruits of all major horticultural classes has, in the last few years, stimulated much interest in these compounds. Advances in research on glycosidic flavor precursors of plant-derived foods has been the subject of several recent reviews (1-4). 

---