Glycosaminoglycans enzymatic polymerization

Kobayashi S, Morii H, Itoh R, Kimura S, Ohmae M. Enzymatic polymerization to artificial hyaluronan a novel method to synthesize a glycosaminoglycan using a transition state analogue monomer. J. Am. Chem. Soc. 2001 123 11825-11826. 

Enzymatic Polymerization In Vitro Synthesis of Glycosaminoglycans and Their Derivatives... 

Keywords Cellulose Chitin Enzymatic polymerization Glycosaminoglycan Polysaccharide... 

Figure 1. Kinetics of skin wound contraction in the presence of polymeric grafts which undergo enzymatic degradation at two different rates, R = 17 enzyme units (e.u.) and R = 231 e.u. The variation in R was achieved by controlling the duration of cross-linking of the collagen-graft-glycosaminoglycan in aqueous glutaraldehyde.

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