Glycosaminoglycans disease associations

Murphy, J. V., Wolfe, H. J., Balazs, E. A., and Moser, H., A patient with deficiency of arylsulfatase A,B,C, and steroid sulphatase associated with storage of sul tide, cholesterol and glycosaminoglycans. In Lipid Storage Diseases (J. Bernsohn and H. Gorsman, eds.), pp. 67-110. Academic Press, New York, 1971. 

Transmission electron microscopy analysis revealed a marked expansion of the endomysial space in thyroid eye disease extraocular muscle biopsies compared with that in control biopsies (69). An increased number of collagen fibers with hyaluronan were detected by immunogold staining, although the serum levels of hyaluronan and urinary glycosaminoglycans were not found to be sensitive indicators for the presence of these molecules within the extraocular muscles (69). Imai et al. further confirmed that the local accumulation of glycosaminoglycans in thyroid eye disease was not associated with the serum hyaluronan concentration (70). 

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