Glycophorin glycopeptide

One way in which to determine whether one part of the molecule may influence the structure about the N-terminus, or whether the assignments of the [ C]methyl resonances in the C-n.m.r. spectra of fully reductively [ CJmethylated glycophorins A and A are correct is to isolate the various glycophorin glycopeptides that have been produced by enzymic or chemical means. 

Chemical-shift Data and Titration Data" for the N-Terminal Di[ C]methylamino Groups of Glycophorins, Glycophorin Glycopeptides, and Related Peptides and Glycopeptides... 

Work with Glycopeptides Derived from Glycophorin A, and with Some Related... 

C Chemical-shift Data and Titration Data for the N-Terminal Mono( C)methyIamino Groups of Glycophorin-related Glycopeptides and Peptides ... 

V. Bencomo and P. Sinay, Synthesis of M and N active glycopeptides. Part of the N-terminal region of human glycophorin A, Glycoconjugate J. 1 5 (1984). 

M. Ciommer and H. Kunz, Synthesis of glycopeptides with partial structure of human glycophorin using the fluorenylmethoxycaibonyl/allyl ester protecting group combination, Synleti p. 593 (1991). 

In experiments designed to explore whether there is protein transverse asymmetry in membranes, it was shown that when trypsin was used to treat intact erythrocytes, the carbohydrate groups of tiie transmembrane protein glycophorin were released from the N-terminus of this protein (as glycopeptides). This was taken as evidence that the N-terminus of glycophorin must be on the exterior side of the membrane because ... 

Paulsen, H, Schultz, M, Klamann, J-D, Waller, B, Paal, M, Building units of oligosaccharides, LXVI. S3mthesis of O-glycopeptide blocks of glycophorine, Liebigs Arm. Chem., 2028-2048, 1985. 

Nakahara et al. accomplished an early s)uithesis of a trimeric a2-6 sialyl-TN glycopeptide. The resultant glycopeptide corresponds to a partial structure of glycophorin A [103] (O Scheme 19). 

Chen J, Chen G, Wu B, Wan Q, Tan Z, Hua Z, Danishefsky SJ (2006) Mature hmnogeneous erythropoietin-level building blocks by chemical synthesis the EPO 114—166 glycopeptide domain, presenting the 0-linked glycophorin. Tetrahedron Lett 47 8013-8016... 

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