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Glycopeptides therapy

Other inhibitors of cell wall synthesis. Bacitracin and vancomycin interfere with the transport of pepti-doglycans through the cytoplasmic membrane and are active only against gram-positive bacteria. Bacitracin is a polypeptide mixture, markedly nephrotoxic and used only topically. Vancomycin is a glycopeptide and the drug of choice for the (oral) treatment of bowel inflammations occurring as a complication of antibiotic therapy (pseudomembranous enterocolitis caused by Clostridium difficile), it is not absorbed. [Pg.270]

Which glycopeptide or polypeptide antibiotic is still investigational and not used in the United States for parenteral therapy ... [Pg.555]

TI Nicas, ML Zekel, DK Braun. Beyond vancomycin new therapies to meet the challenge of glycopeptide resistance. Trends Microbiol 5 240-249, 1997. [Pg.280]

Teicoplanin can be nephrotoxic, but less often than vancomycin (6). However, concomitant aminoglycoside therapy in some patients makes the contribution of the glycopeptide antibiotic difficult to assess. Renal toxicity was observed more often in patients receiving the combination of netilmicin plus vancomycin than in patients treated with netilmicin plus teicoplanin (35). Similar differences in nephrotoxicity between vancomycin and... [Pg.3307]

Fortun J, Navas E, Martinez-Beltran J, Perez-Molina J, Martin-Davila P, Guerrero A, Moreno S. Short-course therapy for right-side endocarditis due to Staphylococcus aureus in drug abusers cloxacilhn versus glycopeptides in combination with gentamicin. Clin Infect Dis 2001 33(l) 120-5. [Pg.3309]

Resistance can emerge in susceptible staphylococci during therapy. The Van A phenotype of vancomycin resistance also confers resistance to teicoplanin by altering the cell-wall target so that the glycopeptide does not bind. Strains of enterococci with Van B resistance often remain susceptible to teicoplanin. [Pg.782]

Based on these experiences with a variety of catalyst-dependent, site-selective reactions, we chose to investigate site-selective functionalization of the glycopeptide antibiotics vancomycin (74) and the teicoplanins (75, the congener). These decisions were made for primarily chemical reasons - we were inspired by the high level of chemical complexity exhibited by these molecules. However, we also wished to create the opportunity to contribute new, potentially improved analogs of these so-called antibiotics of last resort to the field of infectious disease therapy [122-125]. The pursuit of analogs of these storied antibiotics is... [Pg.178]

Vancomycin is a glycopeptide antibiotic used in the therapy of severe bacterial infections (49). The monitoring of vancomycin levels is recommended because of its narrow therapeutic index and toxicity. This measurement is especially appropriate for patients with unstable renal functions, who receive high doses of vancomycin or present serious bacterial infections accompanied by important sequestration of liquids when it could be difficult to achieve the optimal therapeutic dose. Most of the methods for vancomycin determination in routine practice are immimoassays. Chromatog-... [Pg.24]


See other pages where Glycopeptides therapy is mentioned: [Pg.493]    [Pg.167]    [Pg.50]    [Pg.143]    [Pg.269]    [Pg.255]    [Pg.222]    [Pg.272]    [Pg.759]    [Pg.2658]    [Pg.2668]    [Pg.705]    [Pg.224]    [Pg.145]    [Pg.749]    [Pg.1371]    [Pg.163]    [Pg.450]    [Pg.267]    [Pg.267]    [Pg.363]    [Pg.2038]    [Pg.288]   
See also in sourсe #XX -- [ Pg.190 , Pg.191 , Pg.192 , Pg.193 , Pg.194 , Pg.195 , Pg.196 , Pg.197 ]




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Glycopeptide

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