Glycogen synthetase deficiency

In experiments, SAMe was found to prevent lipid peroxidation and to normalize the reduced glycogen content of hepatocytes in fiver damage. In further studies, its cytoprotective effect was also confirmed. (163, 166—171, 173, 177—181) This protective effect likewise applied to preneoplastic cell damage. The results concerning the prevention of cholestasis were impressive. In cirrhosis or severe fiver disease, there is a reduction in SAMe synthetase, glutathione, cysteine and phospholipid methyltransferase (together with a simultaneous deficiency in phosphatidylcholine formation, accompanied by disturbed membrane fluidity and decreased activity of Na /K -ATPase and Ca -ATPase). 

Two reports of a new genetic abnormality in primary gout associated with elevated intracellular PP-ribose-P levels and increased PP-ribose-P synthetase have been described in detail at this meeting. The hyperuricemia of glycogen storage disease (Type 1) caused by deficient glucose-6-phosphatase, has been shown by a... 

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