Glycogen phosphorylase inhibitors

So S-S. and M. Karplus (1999). A comparative study of ligand-receptor complex binding affinity prediction methods based on glycogen phosphorylase inhibitors. Journal of Computer Aided Molecular Design 13 243-258. 

A poorly water-soluble glycogen phosphorylase inhibitor with solubility of about 1 mg/mLwas processed into a solid dispersion with 10 wt% drug and 90 wt% HPMCAS using a solvent-based (acetone) spray-drying method. The resulting solid-dispersion particles with a mean diameter of 5-20 microns were shown to be essentially amorphous by a powday diffraction analysis. 

Additionally, computational chemists often use the resulting output alignment of the molecules as input for 3D-QSAR modeling. As already stated, most field-based 3D-QSAR approaches (such as CoMFA) need a pre-aligned set of molecules and the pharmacophore method is certainly one of the best ways to obtain an objective alignment of the compounds. Klabunde et al., for instance, have recently reported the use of a pharmacophore model of human liver glycogen phosphorylase inhibitors together with 3D information from inhibitor-enzyme complexes to derive a predictive CoMFA model [98]. 

Study of Ligand—Receptor Complex Binding Affinity Prediction Methods Based on Glycogen Phosphorylase Inhibitors. 

So, S.-S. and Karplus, M. (1999). A Comparative Study of Ligand-Receptor Complex Binding Affinity Prediction Methods Based on Glycogen Phosphorylase Inhibitors. J.ComputAid. Molec.Des., 13,243-258. 

So SS, Karplus M. Evaluation of designed ligands by a multiple screening method application to glycogen phosphorylase inhibitors constructed with a variety of approaches. J Comput Aided Mol Des 2001 15(7) 613-647. 

Birch AM, Kenny PW, Simpson I, et al. Matched molecular pair analysis of activity and properties of glycogen phosphorylase inhibitors. Bioorg Med Chem Lett 2009 19 850-853. 

Hadady Z, Toth M, Somsak L (2004) C-(P-D-Glucopyranosyl) heterocycles as potential glycogen phosphorylase inhibitors. ARKIVOC vri 140-149... 

Suh, S.W., J.P. Bergher, C.M. Anderson, J.L. Treadway, K. Fosgerau and R.A. Swanson, 2007 Astrocyte glycogen sustains neuronal activity during hypoglycemia studies with the glycogen phosphorylase inhibitor CP-316, 819 ([R-R, S ]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-l-(phenylmet hyl) propyl]-lH-indole-2-carboxamide). J Pharmacol Exp Ther 321,45-50. 

Figure 6.2 Diverse triazolyl glycoconjugates as glycogen phosphorylase inhibitors.

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