Glycogen initiator synthetase

Stage 1. Assembly of Primer. In 1972 Krisman first provided firm evidence to show that a glycoprotein primer was required for the synthesis of glycogen. Subsequently Krisman and Barengo (1975) extended this study and distinguished between a glycogen initiator synthetase and the well-known glycogen synthetase of liver. 

Glycogen initiator synthetase was a membrane-bound enzyme. In the presence of high concentrations of salt it was shown to add glucosyl residues from UDPGlc to a protein acceptor, so that they became attached by a bond which was labile to acid. These glucosyl residues were 1,4-linked and... 

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