Glycodendrimer dendrimers

RG. 66. Commercially available dendrimer scaffolds commonly used for glycodendrimer syntheses, and general synthetic strategies for synthesis of glycodendrimers. 

The same group modified the linker by using different numbers of carbon atoms (1, 5, 10) to afford variations of the local saccharide concentrations at the dendrimer surface.418 This study was aimed to determine the influence of this linker parameter on the glycodendrimer-protein interactions, the relationship between structure and water solubility, and to investigate amphiphilic properties. 

Furthermore, to avoid the anticipated limitation upon the growth of this type of dendrimer, common when saccharides contain protecting groups, Jayaraman and Stoddart focused on synthesis of glycodendrimers wherein the saccharides were totally unprotected during construction.428... 

K. Bezouska, Design, functional evaluation and biomedical applications of carbohydrate dendrimers (glycodendrimers ), Rev. Mol. Biotechnol., 90 (2002) 269-290. 

GLYCODENDRIMERS BASED ON POLY(AMIDOAMINES) (PAMAM) DENDRIMERS... 

Figure 13.10 Synthesis of mannose-/glucose-functionalized dendrimers. For dendrimer loading, x + y = 50% loading was used because optimal activity for glycodendrimers with concanavalin A was previously determined to occur at 50% functionalization. Remaining amines from the poly(amido amine) (PAMAM) substrate were capped as alcohols.

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