Glycine-rich sequence

Bossemeyer, D. The glycine-rich sequence of protein kinases a multifunctional element (1994) Trends Biochem. Sd. 19, 201-205... 

Fig. 11.7 The glycine-rich sequences of adenylate kinase, ras protein, and the fi subunit of Fi-ATPase.

Amino acid sequence of adenylate kinase (Adk), ras protein and the fi subunit are aligned. The conserved glycine-rich sequence is shown (bottom). The secondary structures of adenylate kinase... 

Amino Acid Residues Interacting with Glycine-rich Sequence... 

Analysis of pseudorevertants (or suppressor) of unc mutants is a unique approach to find functional and/or structural interactions) between the two amino acid residues in the complex enzyme. Residues near the -y-phosphate moiety of ATP could be mapped relative to the residues in the glycine-rich sequence by identifying pseudorevertants of the mutants in the glycine-rich sequence. Conversely, other residues can also be mapped closely to the glycine-rich sequence, if effects of their mutations are suppressed by mutations in the glycine-rich sequence. 

Figure 2-4 Informational content analysis of the ALAS2 glycine-rich loop. Functionally acceptable amino acid substitutions at each position are indicated. The wild-type murine ALAS2 glycine-rich sequence is shown in a shaded box. Results obtained with random mutagenesis and glydne-rich loop codon specific libraries are indicated above and below the wild-type sequence, respectively. (Adapted from [86]).

Fukushima, Y. Genetically engineered syntheses of tandem repetitive polypeptides consisting of glycine-rich sequence of spider draghne silk. Biopolymers 45, 269-279 (1998). 

From the size of the crystallites as well as the measured intersheet spacing it was concluded that the crystalline domains must also include glycine rich sequence parts [56-58, 61]. The inclusion of GGX motifs, however, is still an open issue [62]. 

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