Glycerol phosphate pathway

Figure 24-2. Biosynthesis of triaq/lglycerol and phospholipids. ( , Monoacylglycerol pathway (D, glycerol phosphate pathway.) Phosphatidylethanolamine may be formed from ethanolamine by a pathway similar to that shown for the formation of phosphatidylcholine from choline.

The major pathways for triacylglycerol synthesis are shown in Fig. 11.17. The formation of phos-phatidic acid by the glycerol phosphate pathway or the dihydroxyacetone phosphate pathway has already been discussed (Section 11.2.11). In addition, see reviews by Gurr (1980) and O Doherty (1978). Phosphatidic add can also be formed from... 

Sun, C., Cao, Y.-Z. and Huang, A.H.C. (1988) Acyl coenzyme A preference of the glycerol phosphate pathway in the microsomes from the maturing seeds of palm, maize and rapeseed. Plant Physiol. 88, 56-60. 

The monoacylglycerol pathway has also been demonstrated in the adipose tissue of the hamster and the rat. Under certain conditions it appears to compete with the glycerol phosphate pathway for acyl groups and may serve to regulate the activity of the latter pathway. The origin of the monoacylglycerol substrate in adipose tissue is not known. 

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