Glycerol Ether Phosphatides

Pettitt, T.R., Martin, A., Horton, T., liossis, C, Lord, J.M., and Wakelam M.J.O., 1997, Ehacyl-glycerol and phosphatidate generated by phospholipases C and D, respectively, have distinct fatty add compositions and functions. J. Biol. Chem. 272 17354 17359 Powis G., Seewald, M.J., Gratas, C., Melder, D., Riehow, J., and Modest, E.J., 1992, Selective inhibition of phosphatidyUnositol phosphohpase C by cytotoxic ether hpid analogs. Cancer Res. 52 2835-2840... 

I. B. Cushing (synthesis of 8-phosphatidic acids), A. M. Newcombe (preparation of L-a-guaiaeyl glycerol ether) and D. L. MacDonald, who was to accompany Fischer to the University of California and collaborate with him in a number of outstanding achievements in the carbohydrate field. The post-doctoral level, too, was represented in the persons of Henry... 

Glycerophospholipids contain a glycerol skeleton to which two fatty acids are esterified saturated fatty acids occupy mostly sn-position 1, whereas unsaturated fatty acids are mainly present on sn-position 2. The third hydroxyl is linked to a phosphate group to which an organic base is mostly esterified (Fig. 1). The most important components of soybean lecithin are phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). Phosphatidic acid (PA) may become important due to the presence of phospholipase D this enzyme slowly converts PC into PA in vegetable lecithins. Phosphatidylserine (PS), phosphatidylglycerol (PG), and lyso-phosphatidylcholine (LPC) are known as minor components lysophospholipids contain only one acyl group per molecule. Besides, ether phospholipids occur in which one or both fatty acyl... 

Various other derivatives such as ether-containing and glycerol analogues of phosphatidic acid have been synthesized (Rosenthal, 1975). 

Plasmalogens ( acetal phosphatides ) Glycerol ester and enol ether Ethanolamine, choline 1 1... 

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