Glyceritol 1-0-methyl

Recently, Putman and Hassid have confirmed93 the structural formula given by Colin and Gueguen. Methylation of floridoside, followed by hydrolysis, gave 2,3,4,6-tetra-O-methyl-D-galactose and 1,3-di-O-methyl-glyceritol (identified by its lack of optical rotation, and by mixed melting point of its p-nitrobenzoate with the authentic ester). Periodate-oxidation studies on floridoside also confirmed the earlier formula. 

In 1926, Berl and Bitter studied the action of sodium hydroxide and carbon disulfide upon ethylene glycol, glyceritol, and their methyl ethers, and concluded that, whilst one vacant hydroxyl group is essential for occurrence of esterification, the presence of additional free hydroxyl groups inhibits reactivity. They failed to achieve xanthation of even the mono-hydric compounds in the presence of an equimolar proportion of water, unless activated carbon was also added. By using various 0-methylated celluloses, they were able to demonstrate that, for maximum esterification, two free hydoxyl groups for each D-glucopyranose residue are necessary. 

Related to the interpretation of the effects of radiation on nucleic acids are the studies on the formation of labile phosphate esters in solutions of simple phosphates by irradiation. When glyceritol 1- and 2-phosphates are irradiated with 200 KV x-rays, inorganic phosphate is liberated. The former gives l,3-dihydroxy-2-propanone phosphate, and the latter, an acid-labile phosphate ester. " Detailed studies on methyl, ethyl, propyl, butyl, and amyl phosphates have indicated the mode of formation of such labile phosphate esters. Two reactions have been recognized ... 

The oxidation product from methyl 6-0-trityl-a-D-glucopyranoside has been used in the preparation of 1-0-methyl-L-glyceritol. The oxidation product from methyl 5,6-di-O-methyl-a-D-glucoside has been used in the preparation of 1,2-di-O-methylerythritol. ... 

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