Glycans structures common

Figure 2 Mammalian monosaccharides and nucleotide sugars. (A) Chemical structures, common names, and abbreviations of the 11 monosaccharides found in mammalian glycans as well as ManNAc, the precursor for sialic acids. (B) Examples of the three classes of nucleotide sugars are provided by UDP-GIcNAc (Glc, GIcA, Gal, GalNAc, and Xyl also use UDP), GDP-Man (Fuc also is linked to GDP), and CMP-Neu5Ac/Gc (IdoA is produced by postsynthetic epimerization of GIcA and therefore does not require a nucleotide sugar).

More recently, the trichloroacetimidate strategy has been applied to the synthesis of a branched pentasaccharide unit common to most complex Af-glycan structures (Scheme 10). Reaction of marmosyl donor 57 with thiol-functionalized resin resulted in attachment to the polymer matrix through the reducing end of the sugar... 

Fig. 1. The structure of GPI anchors. All characterized GPl anchors share a common core consisting of ethanol-amine-P04-6Man(al-2)Man(al 6)Man(al-4)GlcN(al-6)m) o-lno-l-P04-lipid. Heterogeneity in GPl anchors is derived from various substitutions of this core structure and are represented as R groups. R] and R2 may be long chain fatty acyl or alkyl groups or ceramide. R3 is frequently palmitate positioned at either C2 or C3 of the inositol ring. R4 and R7 are additional phosphoethanolamines. R5, R and Rg may be various glycan substitutions. The few known substituted glycan structures are indicated. (Redrawn from ref [18].)...

TABLE 6.4 Enzymes commonly used in glycan structure analysis... 

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