Glycan primary structures

Important variations of the plasma serotransferrin concentration are observed in physiological and pathological situations. They are often accompanied by dramatic modifications of glycan primary structure (see section 3.2). 

Comparative study of transferrin glycan primary structures... 

Interestingly, the glycan primary structure of lactotransferrin extracted from human polymorphonuclear leukocytes is identical to that of the non-fucosylated diantennary... 

Physiopathological modifications of transferrin glycan primary structure... 

IgE reactivity to these V-glycans have been studied and compared with IgE reactivity to a number of glycoproteins of known primary structures. These differences can induce undesirable immune responses in mammals and/or reduce the activity of recombinant proteins. 

J. Montreuil, Primary structure of glycoproteins glycans Bases for the molecular biology ol glycoproteins, Adv. Carbohydr. Chem. Biochem. 37 153 (1980). 

PRIMARY STRUCTURE OF GLYCOPROTEIN GLYCANS BASIS FOR THE MOLECULAR BIOLOGY OF GLYCOPROTEINS... 

It then clearly appeared that complete knowledge of the primary structure and conformation of the glycans was necessary, first, to establish the relationships between structure and specific biological activity, and second, to explain the pathogenesis of the glycoprotein-... 

J. Montreuil and J. F. C. Vliegenthart, Primary Structure and Conformation of Glycans N-Glycosidically Linked to Peptidic Chains, Proc. Int. Siimp. Glycoconjugates, 4th, Woods Hole, 1977, Academic Press, New York, 1979, pp. 35-78. 

However, some results will be briefly described that lie outside classicism, and that concern the control of glycan biosynthesis by the primary structure of the peptide chain and by the oligosaccharide motifs carried by the glycan itself. 

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