Glycan groups

A polysaccharide (glycan) composed entirely of glycuronic acid residues is named byreplacing -icacid by -an . The generic name for this group of polysaccharides is glycuronan . 

Ramirez-Soto, D. and Poretz, R.D. (1991) The (l-3)-linked (X-L-fucosyl group of the IV-glycans of the Wistaria floribunda lectins is recognised by a rabbit antiserum. Carbohydate Research 213, 27-36. 

The modification of molecules with saccharides also has the effect of increasing the hydrophilicity of the resultant complex due to the presence of multiple hydroxyl groups. Native glycan modification of proteins functions in much the same manner, because the carbohydrate... 

Add to the glycan solution the molecule to be labeled containing an available amine, hydrazine, or hydrazide group. For small molecule derivatization, the final concentration of the nucleophile in the glycan solution should be about 0.3 M to result in maximal efficiency of labeling. For protein modification, an aqueous reaction buffer should be used, and the protein should be as concentrated as possible. 

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