Glutathione formation

J. M. Wilhamson, A. Meister, Stimulation of Hepatic Glutathione Formation by Administration of L-2-Oxothiazohdine-4-carboxylate, a 5-Oxo-L-prolinase Substrate , Proc. Natl. Acad. Sci. U. S. A. 1981, 78, 936 - 939. 

Glutathione formation induction. Water extract of the fresh root, administered intragastrically to infant mice at a dose of 25 mL/kg, was active. The treatment was administered for seven successive days followed by a single dose of 20% v/v CCl in olive subcutaneously at 1 mL/kg on the last day, 1 hour after the administration of the carrot extract . ... 

Williamson, J. M., Meister, A. Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a... 

Figure 4 Correlation between glutathione level and peroxidative ethane formation in bean leaves. The glutathione level was changed either by an enhancer (no. 1) or by inhibitors (nos. 3,4,5) of glutathione formation (see text).

Rate of reduced glutathione formation under steady-state illumination. 

Trichloroethylene was acutely cytotoxic to proximal and distal tubular cells isolated by coUagenase perfusion from the kidneys of male Fischer 344 rats only at high concentrations, but, under conditions in which cytochrome P450 was not inhibited, S-(l,2-dichlorovinyl)glutathione formation was detected only in proximal tubular cells (Cummings etal. 2000). Inhibition of cytochrome P450 resulted in increases in both cytotoxicity and biotransformation of trichloroethylene. 

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