Glutathione-citryl thioester

Transfer of citrate through the inner membrane of MCh is provided by a tricarboxylate transporter (m.w. 32.5 kD), which also catalyzes transport of treo-Ds-isocitrate, cis-aconitate and other tricarboxylates (LaNoue and School-werth, 1979 Kaplan et al, 1990). This is electroneutral exchange for either another tricarboxylate or dicarboxylate (e.g. malate or succinate), or for phosphoenolpyruvate. Formation of glutathione-citryl thioester is irreversibly inhibited by (-)erythrofluorocitrate (IC50 = 25 pmol FC/mg protein), which makes a stable adduct with the synthase (Kun et al, 1977). However, the block of citrate transport... 

Kun, E., Kirsten, E., Sharma, M.L. (1977). Enzymatic formation of glutathione-citryl thioester by a mitochondrial system and its inhibition by (-)erythrofluorocitrate (glutathione-S-citryl ester/metalloprotein/inner mitochondrial membrane/fluoroci-trate toxic mechanism). Proc. Natl Acad. Sci. USA 74 4942-6. 

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See also in sourсe #XX -- [ ]

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