Glutathione cerebrospinal fluid

Lee YJ, Kusuhara H, Sugiyama Y. Do multidrug resistance-associated protein-1 and -2 play any role in the elimination of estradiol-17 beta-glucuronide and 2,4-dinitrophenyl-S-glutathione across the blood-cerebrospinal fluid barrier J Pharm Sci 2004 93 99-107. 

Do KQ, Trabesinger AH, Kirsten-Kruger M, Lauer CJ, Dydak U, et al. 2000. Schizophrenia Glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo. Eur J Neurosci 12 3721-3728. 

Glutathione synthesis is impaired in patients at the level of the GCL enzyme, as measured in fibroblasts. In addition, genetic analysis showed an association between schizophrenia and the two GCL subunits. These findings are consistent with low brain and cerebrospinal fluid (CSF) glutathione levels. 

Tohgi H, Abe T, Yamazaki K, Murata T, Ishizaki E, Isobe C (1999) Increase in oxidized NO products and reduction in oxidized glutathione in cerebrospinal fluid from patients with sporadic form of amyotrophic lateral sclerosis. Neurosci Lett 260 204-206. 

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