Glutaronitrile, 3-hydroxy

Glutaronitrile, 3-hydroxy-, 46, 48 Glycerol chlorohydrin, 46, 24 Glycine (-butyl ester, 45, 47 conversion to acetamidoacetone, 45,1 Glyoxal, phenyl-, 48,109 Glyoxals from esters and the potassium salt of dimethyl sulfoxide, 48, 112... 

Bergeron, S., Chaplin, D.A., Edwards, J.H. et al. (2006) Nitrilase-catalyzed desymmetrization of 3-hydroxy-glutaronitrile preparation of a statin side-chain intermediate. Organic Process Research Development, 10, 661-665. 

Reduction of 2-furoyl chloride [225] at mercury in MeCN containing TEAP affords a variety of products, the most prominent of which is 1,2-di(2-furyl)ethene-l,2-diol di(2-furoate), along with small quantities of 2-furaldehyde, furil, furoin, hydro-furoin, l,2-di(2-furyl)-2-hydroxy-3-cyanopropanone, and 3-(2-furyl)acrylonitrile. Electrolysis of 2,4,6-trimethylbenzoyl chloride [226] at carbon and mercury in MeCN containing TEAP gives mainly 2,4,6-trimethylbenzaldehyde and 3-(2,4,6-trimethylphen-yl)acrylonitrile however, traces of 2,4,6-trimethylbenzene, 2,4,6-trimethylbenzyl alcohol, 3-(2,4,6-trimethylphenyl)glutaronitrile, and 3-(2,4,6-trimethylphenyl)propionitrile are formed. 

Atorvastatin (Lipitor) enzymatic desymmetrization of 3-hydroxy-glutaronitrile. 

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