2-Methyl glutaric acid

P-METHYL-P-PHENYLGLUTARIC ACID (Glutaric acid, 3-methyl-3-phenyl-)... 

The addition of various Kolbe radicals generated from acetic acid, monochloro-acetic acid, trichloroacetic acid, oxalic acid, methyl adipate and methyl glutarate to acceptors such as ethylene, propylene, fluoroolefins and dimethyl maleate is reported in ref. [213]. Also the influence of reaction conditions (current density, olefin-type, olefin concentration) on the product yield and product ratios is individually discussed therein. The mechanism of the addition to ethylene is deduced from the results of adsorption and rotating ring disc studies. The findings demonstrate that the Kolbe radicals react in the surface layer with adsorbed ethylene [229]. In the oxidation of acetate in the presence of 1-octene at platinum and graphite anodes, products that originate from intermediate radicals and cations are observed [230]. 

Benzyl Methyl Ketone Beta Keto Glutaric Acid mono-Bromobenzene Butacaine... 

VINYL PROPIONATE 2-HYDROXYETHYL ACRYLATE LEVULINIC ACID METHYL ACETOACETATE GLUTARIC ACID VALERONITRILE n-BUTYL ISOCYANATE N-HETHYL-2-PYRROLIDONE L-GLUTAMIC ACID CYCLOPENTANE 2-METHYL-1-BUTENE... 

Glutaric acid, 3-[l-(hydroxy-methyl)-trans-l-propenyl] Fr 6.9 ... 

Frank, J., Eliasson, C., Leroy-Nivard, D., Budek, A., Lundh, T., Vessby, B., Aman, P., and Kamal-Eldin, A., Dietary secoisolariciresinol diglucoside and its oligomers with 3-hydroxy-3-methyl glutaric acid decrease vitamin E levels in rats, Br. J. Nutr., 92, 169, 2004. 

If the alkyl group of a /3-alkyl-/3-phenyl-a,c/-dicyanoglu-tarimide is larger than the methyl group, the hydrolysis to the corresponding glutaric acid should be modified as described by McElvain and Clemens, J. Am. Chem. Soc., 80, 3915 (1958). 

This synthesis has one rather anomalous application, when a-bromo-isobutyric acid (or its ethyl ester) is heated with silver, some tetramethyl-succinic acid is produced in the ordinary way (B., 23, 297 26, 1458). But there also appears trimethylglutaric acid (A., 292, 220). To explain the unexpected formation of this acid, it has been assumed that a portion of the a-bromoisobutyric acid gives up HBr to form methylacrylic acid. This latter then forms j3-bromoisobutyric acid, and the silver withdraws bromine from the a- and /3 acids, whereby the residues unite to tri-methyl-glutaric acid (B., 22, 48, 60). A similar explanation applies to some other syntheses in which tetramethylsuccinic and trimethylglutaric acids appear together. 

Dimethyl-D-arabinose has been obtained29 from 3-/J-D-galacto-pyranosyl-D-arabopyranose, obtained by the Wohl-Zempl6n degradation of lactose, by methylation and hydrolysis. Oxidation with nitric acid gave /9-hydroxy-aY-dimethoxy-D-arabo-glutaric acid, the amide of which was the enantiomorph of the product obtained from 2,4-dimethyl-L-arabinose. 

As mentioned in the introduction, trimethyl-L-arabofuranose is frequently found among the products of hydrolysis of methylated polysaccharides. The sugar was first isolated by the methylation of methyl L-arabofuranosides (a/3 mixture) with silver oxide and methyl iodide.46 Oxidation of the free sugar with nitric acid gave a dimethoxyhydroxy-glutaric acid. 

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