7-Glutamyl-cysteine synthetase mechanism

GSH-peroxidase because of detoxification of putatively increased amounts of hydroperoxides. Therefore, it seems crucial to protect cells from loss of antioxidants and potent reducing substances, such as NADPH or NADH. In turn, depletion of cells from ATP by inhibition of oxidative phosphorylation could result in decreased activity of 5-oxoprolinase, glutamyl-cysteine-synthetase and GSH synthetase, all known to be dependent on ATP (Meister, 1991), resulting in impaired detoxification mechanisms and subsequent cell damage because of oxidative stress. 

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