Glutamate solubility

The solubility properties of 21 render it an excellent support for benzyl glutamate grafting. Reaction of various ratios of NCA/amine ratios yielded grafts of the predicted chain length. The graft copolymers were completely soluble in THF and CHCI3 and could be cast into films. The unique properties of these materials are under investigation. 

Synthetic Polymers. Synthetic polymers are versatile and offer promise for both targeting and extracellular-intracellular drug delivery. Of the many soluble synthetic polymers known, the poly(amino acids) [poly(L-lysine), poly(L-aspartic acid), and poly(glutamic acid)], poly(hydroxypropylmethacrylamide) copolymers (polyHPMA), and maleic anhydride copolymers have been investigated extensively, particularly in the treatment of cancers. A brief discussion of these materials is presented. 

Chitosan is insoluble at alkaline and neutral pH values but it can form salts with inorganic and organic acids such as hydrochloric acid, lactic add, acetic add and glutamic acid. In contrast to alginates and carrageenans in solution, the amino fundions of chitosan are protonated and the resultant soluble polysaccharide is... 

Two asymmetric carbon atoms, the or carbon in the glutamic acid portion of the molecule and the C6 carbon in the tetrahydropteridine ring, allow four possible isomers. Since synthetic procedures would undoubtedly start with L-glutamic acid, the isomeric possibilities are reduced to the dL and 1L diastereomers. Of these, the biologically more active form is the 1L separation of the diastereomers is effected by solubility differences of the calcium salts.2... 

F (increases in alkaline phosphatase(48%), glutamate oxaloacetate transaminase (82%) glutamate pyruvate transaminase (55%), isocitrate dehydrogenase (65%), cholesterol (27%-35%), and soluble proteins (35%) decreases in free amino acids (34-40%) and glucose (41-51%) vacuolization fatty infiltration)... 

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