Glutamate-evoked current, dendritic

ON Input As noted earlier, mitral/tufted cell apical dendrites respond to glutamate released from the ON via AMPA and NMDA receptors (Ennis et al., 1996, 2001 Aroniadou-Anderjaska et al., 1997 Chen and Shepherd 1997). The NMDA receptor-mediated response component is of unusually long duration, leading to a late spiking component in response to ON input (Ennis et al., 1996, 2001 Aroniadou-Anderjaska et al., 1997). An mGluR-mediated component of ON-evoked currents in mitral cells also occurs but is typically small under normal conditions (De Saint Jan and Westbrook, 2005 Ennis et al., 2006), yet, as will be discussed later, blockade of these receptors significantly alters ON-evoked spiking. 

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