Glutamate dehydrogenase NADP-linked

For glyceraldehyde-3-phosphate dehydrogenase, glutamate dehydrogenase, and the NADP-linked oxidative decarboxylases, which have three substrates in one direction, initial rate measurements with a fixed concentration of any one of the three substrates also conform to Eq. (1). This again rules out any form of enzyme-substitution mechanism in which free product is formed before all the substrates have combined with the enzyme and indicates the involvement of a quaternary enzyme complex. The appropriate generalized form of Eq. (1) is... 

In yeast grown under hypoxic conditions succinate accumulates and the Krebs cycle is split in two branches, one diverging from oxaloacetate to succinate with simultaneous NAD recovery and the other one from oxaloacetate to glutamate, in which the NADP-linked isocitrate dehydrogenase produces the substrates needed for the NADP-linked glutamate dehydrogenase, namely 2-oxoglutarate and NADPH.< )... 

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