Glutamate-binding domain

Figure 32.18. Schematic Structure of a Metabotrophic Glutamate Receptor. The umami receptor is a variant of a brain glutamate receptor. A substantial part of the high-affinity glutamate-binding domain (shown in yellow) is missing in the form expressed in the tongue.

Ahmed AH, Wang Q, Sondermann H et al (2009) Structure of the S1S2 glutamate binding domain of GLuR3. Proteins 75 628-637... 

Arinaminpathy, Y Sansom, M. S. P, and Biggin, B. C. (2002) Molecular Dynamics simulations of the ligand binding domain of the ionotropic glutamate receptor GluR2. Biophys. J. 82,676-693. 

O Hara, P. J., Sheppard, P. O., Thpgersen, H., et al. (1993) The ligand-binding domain in metabotropic glutamate receptor is related to bacterial periplasmic binding proteins. Neuron 11,41-52. 

El Far, O., Bofill-Cardona, E Airas, J. M O Connor, V., Boehm, S., Freissmuth, M et al. (2001) Mapping of calmodulin and Gpy binding domains within the C-terminal region of the metabotropic glutamate receptor 7A. J. Biol. Chem. 276, 30662-30669. 

Hampson DR, Huang XP, Pekhletski R, Peltekova V, Hornby G, et al. 1999. Probing the ligand binding domain of the mGluR4 subtype of metabotropic glutamate receptor. J Biol Chem 274 33488-33495. 

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