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Glucuronidation species defects

Studies on the metabolic fate of phenol in several species have indicated that four urinary products are excreted (Figure 9.5). Although extensive phenol metabolism takes place in most species, the relative proportions of each metabolite produced varies from species to species. In contrast to the cat, which selectively forms sulfate conjugates, the pig excretes phenol exclusively as the glucuronide. This defect in sulfate conjugation in the pig is restricted to only a few substrates, however, and may be due to the lack of a specific phenyl sulfotransferase because the formation of substantial amounts of the sulfate conjugate of 1-naphthol clearly indicates the occurrence of other forms of sulfotransferases. [Pg.177]


See other pages where Glucuronidation species defects is mentioned: [Pg.232]    [Pg.177]    [Pg.286]    [Pg.762]    [Pg.33]    [Pg.184]    [Pg.220]    [Pg.288]    [Pg.252]    [Pg.39]   
See also in sourсe #XX -- [ Pg.10 , Pg.20 ]




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