Glucosinolates, oxime metabolism

CYP79s in the Biosynthesis of Cyanogenic Glucosides and Glucosinolates 233 The Oxime-Metabolizing Enzyme as Branch Point between the Cyanogenic... 

Molecular Identification of Oxime-Metabolizing Enzyme in Glucosinolate... 

THE OXIME-METABOLIZING ENZYME AS BRANCH POINT BETWEEN THE CYANOGENIC GLUCOSIDE AND THE GLUCOSINOLATE PATHWAY... 

S. alba has been used as a model plant for biochemical studies of the oxime-metabolizing enzyme in the biosynthetic pathway of glucosinolates.33 The major... 

Mahadevan reviewed research up to 1973, with respect to the pathways of oxime metabolism in plants, and evaluated a series of aliphatic and aromatic oximes that are precursors for the biosynthesis of plant secondary metabolites (as opposed to basic metabolism products that are essential for cell survival), such as cyanogenic glycosides, glucosinolates and certain phytohormones . Some of these oximes are shown below. 

K. B. Axelsen, A.X Hick et al. (2001). CYP83BI is the oxime metabolizing enzyme in the glucosinolate pathway in Arabidopsis. J. Biol. Chem. 276, 24790-24796. 

Figure 13.5 Metabolic engineering of oxime-derived natural products in Arabidopsis plants. Up- and downregulation of endogenous as well as exogenous CYP79s provides a powerful tool for alteration of the glucosinolate profiles and introduction of novel glucosinolates, as well as for engineering oxime-derived natural products.

NAUR, P., PETERSEN, B.L., MIKKELSEN, M.D., BAK, S RASMUSSEN, H., OLSEN, C.E., HALKIER, B.A., CYP83A1 and CYP83B1, two nonredundant cytochrome P450 enzymes metabolizing oximes in the biosynthesis of glucosinolates in Arabidopsis., Plant Physiol., 2003, 133, 63-72. 

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