Glucose metabolism biguanide effects

Moreover, the relative sensitivity of the tissues was in the same order as the relative sensitivity of the three species to the hypoglycemic action of the biguanides. In another investigation, a number of the effects of phenformin on metabolism in rat adipose tissue,— Inhibition of glucose oxidation and lipogenesis, both basal and insulin stimulated— were traced to an inhibition of pyruvate oxidation, presumably resulting from interference with electron transport. 

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