Glucose ester conjugates, formation

Formation of sulfate esters is one of the metabolic conjugation reactions (phase II reactions, see Chapter 31). Sulfates of estradiol, glucose, menadiol, and hydro-xyethyl-theophylline have been prepared (Fig. 36.9). As a rule sulfuric acid esters, compared with their phosphoric analogues, are resistant to enzymatic hydrolysis in and their conversion to the parent drug is questionable. 

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