Glucose analogues

This class of carbohydrates has not been found in Nature. The absence of 5-OH group restricts the sugar to the furanose ring form. The first synthetic 5-deoxyhexose was the glucose analogue, 5-deoxy-D-. v/o-hexose (40), and the different methods reported have been reviewed by Overend.97 One of the obvious approaches was the reduction of compounds conveniently derivatized at C-5. For example, treatment of the 5-tolylsulfonyl derivative 38, with lithium aluminum hydride gave compound 39, which upon deprotection led to 40. 

F-labeled glucose analogues Uptake differences PET imaging 73... 

TABLE 4,1 I ransport of Glucose and a Glucose Analogue into Cells... 

Inhibition Constants for Glucose Analogues with Glycogen Phosphorylase b + AMP... 

Fig 3.5. Experimentally measured label concentration in a mycelium of Arthrobotrus superba growing out from a piece of wood into soil. The top diagram shows the distribution of labelled non-metabolizable glucose analogue added to the wood in trace amounts. The bottom diagram shows the distribution of added to the wood in trace amounts. 

A labelled glucose analogue an indirect probe to measure energy metabolism... 

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