Glucosamine preparation

D-glucosamine preparation. This labile phosphate derivative is inactive as a substrate. Since the d anomer of D-glucosyl phosphate is more acid-labile than is the a anomer/ the a anomer of iV-acetyl-D-glucosamine 1-phosphate is considered to be involved in this reaction. ... 

Dibenzyl phosphoramidates have been prepared from amino acids and the j)hos-phoryl chloride, (Bn0)2P(0)Cl. ° A diphenyl phosphoramidate has been prepared from a glucosamine it is converted by transesterification into a dibenzyl derivative to facilitate cleavage. ... 

The preparation of glucosamine hydrochloride from lobster shells and crab shells by essentially this method has been reported by Irvine, McNicoll, and Hynd and Hudson and Dale. Other methods involving the use of cicad larvae shells and shrimp shells ls also have been reported. 

Ledderhose, G. Z. Physiol. Chem. (ZPCHA5) 2, 213 (1878). preparation of glucosamine salts ... 

Mo 1AR92236 QuReport Prepared by Hines Bfostatifitical Center Report No, 102 - Z ... 

Preparations from various sources show closely similar properties, e. g., nitrogen 3-3.5%, D-glucosamine 30-40%, D-glucuronic acid 40-45%, acetyl 8-12%, [o]d —60 to —70° in water. 

In all cases where the chemical properties of these preparations have been studied the active material appears to be predominantly carbohydrate in nature, containing in the case of the A factor 50-70% of reducing sugar, 5.7% nitrogen and giving by colorimetric estimations 25-30% of glucosamine on hydrolysis. 

Other Methods of Preparation.—Ethyl 2-(D-oro6ino-tetrahydroxybutyl)-5-methyl-4-pyrrolecarboxylate has also been prepared by the reaction of D-glucosamine with ethyl acetoacetate.81... 

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