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Glimepiride Fluconazole

The effects of fluconazole and fluvoxamine on the pharmacokinetics and pharmacodynamics of glimepiride have been studied in a randomized, double-blind, crossover study in 12 healthy volunteers who took fluconazole 200 mg/day (400 mg on day 1), fluvoxamine 100 mg/day,... [Pg.452]

Niemi M, Backman JT, Neuvonen M, Laitila J, Neuvonen PJ, Kivisto KT. Effects of fluconazole and flu-voxamine on the pharmacokinetics and pharmacodynamics of glimepiride. Clin Pharmacol Ther... [Pg.458]

A double-blind study in 12 healthy subjects found that fluconazole 400 mg on day one then 200 mg daily for a further 3 days increased the AUC and peak plasma level of a single 0.5-mg dose of glimepiride by about 2.5-fold and 1.5-fold, respectively. Fluconazole increased the mean elimination half-life of glimepiride from 2 to 3.3 hours. ... [Pg.479]

See other pages where Glimepiride Fluconazole is mentioned: [Pg.396]    [Pg.452]    [Pg.1384]    [Pg.479]    [Pg.479]   
See also in sourсe #XX -- [ Pg.479 ]



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