GLAST

GLAST/EAAT1 (SLC1A3) Glial cells in cerebellum, retina, inner ear 5-70 ... 

Conradt, M. and Stoffel, W. (1997) Inhibition of the high-affinity brain glutamate transporter GLAST-1 via direct phosphorylation../. Neurochem. 68,1244-1251. 

Gegelashvili G., Danbolt N. C., and Schousboe A. (1997). Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia. J. Neurochem. 69 2612-2615. 

Matsugami T. R., Tanemura K., Mieda M., Nakatomi R., Yamada K., Kondo T., Ogawa M., Obata K., Watanabe M., Hashikawa T., and Tanaka K. (2006). Indispensability of the glutamate transporters GLAST and GLT1 to brain development. Proc. Natl. Acad. Sci. USA 103 12161-12166. 

Perego C., Vanoni C., Bossi M., Massari S., Basudev H., Longhi R., and Pietrini G. (2000). The GLT-1 and GLAST glutamate transporters are expressed on morphologically distinct astrocytes and regulated by neuronal activity in primary hippocampal cocultures. J. Neurochem. 

Suarez I., Bodega G., and Fernandez B. (2000). Modulation of glutamate transporters (GLAST, GLT-1 and EAAC1) in the rat cerebellum following portacaval anastomosis. Brain Res. 

Suarez, I., Bodega, G., Rubio, M., Fernandez-Ruiz, J. J., Ramos, J. A., and Fernandez, B. (2004b). Prenatal cannabinoid exposure down-regulates glutamate transporter expressions (GLAST and EAAC1) in the rat cerebellum. Dev. Murosci. 26, 45—53. 

The central role played by GLAST in the prevention of glutamate neurotoxicity after ischemia is further supported by the observation that GLAST deficient mice show more severe damage after pressure-induced retinal ischemia compared to GLT-1 deficient and wild-type animals (Harada et al., 1998). 

The crucial role played by GLTs in the pathophysiology of glaucoma is strengthened by the observed reduction of GLAST expression (Naskar et al., 2000) in conjunction with the induction of a splice variant of GLT-1 in RGCs (Sullivan et al., 2006) in glaucomatous eyes. 

Pow, D. V., and Barnett, N. L. (1999). Changing patterns of spatial buffering of glutamate in developing rat retinae are mediated by the Muller cell glutamate transporter GLAST. Cell Tissue Res. 297, 57-66. 

Rauen, T., Taylor, W. R., Kuhlbrodt, K., and Wiessner, M. (1998). High-affinity glutamate transporters in the rat retina A major role of the glial glutamate transporter GLAST-1 in transmitter clearance. Cell Tissue Res. 291, 19-31. 

Figure 16.19. Simulation of a gamma-ray annihilation line from the annihilation of 48 GeV neutralinos, superimposed on a gamma-ray background of astrophysical origin. The simulation includes the finite energy resolution of the upcoming GLAST detector. (Figure from the GLAST Science Brochure.)...

Melone M, Bragina L, Conti F. 2003. Clozapine-induced reduction of glutamate transport in the frontal cortex is not mediated by GLAST and EAAC1. Mol Psychiatry 8 12-13. 

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