6-Gingerol pharmacokinetics

Ding GH, Naora K, Hayashibara M, Katagiri Y, Kano Y, Iwamoto K. (1991). Pharmacokinetics of [6]-gingerol after intravenous administration in rats. Chem Pharm Bull (Tokyo). 39(6) 1612-14. Dziedzicka-Wasylewska M, Willner P, Papp M. (1997). Changes in dopamine receptor mRNA expression following chronic mild stress and chronic antidepressant treatment. Behav Pharmacol. 8(6-7) 607-18. [Pg.506]

Naora, K., Ding, G., Hayashibara, M., Katagiri, Y., Kano, Y. and Iwamoto, K. (1992) Pharmacokinetics of [6]-gingerol after intravenous administration in rats with acute renal or hepatic failure. Chemical and Pharmaceutical Bulletin 40(5), 1295-1298. [Pg.95]

No human studies of the pharmacokinetics of any ginger components have been conducted. Only one study in rats has been conducted to examine the pharmacokinetics of a ginger component, 6-gingerol. This study observed that after IV administration, the plasma concentration-time curve was best described by a two-compartment model with a rapid terminal elimination half-life of 7.2 minutes and a total body clearance of 16.8 mL/minute / kg. The protein binding of 6-gingerol was approx 92%. [Pg.160]

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