Platelet aggregation inhibition ginger

Platelet Inhibition Ginger extract has been found to inhibit platelet aggregation induced by arachidonic acid, epinephrine, ADP, and collagen (Srivastava 1984). The extract s ability to inhibit cyclooxygenase activity and thromboxane levels correlated well with inhibition of platelet aggregation (Srivastava 1984 Mustafa et al. 1993). The type of preparation used also affects platelet inhibition, because roasted and charcoal of ginger were effective, while ether extracts of raw and dried ginger were not (Wu et al. 1993). 

Srivastava KC. (1984). Aqueous extracts of onion, garlic and ginger inhibit platelet aggregation and alter arachidonic acid metabolism. Biomed Biochim Acta. 43(8-9) S335-46. 

Ginger, which inhibits thromboxane synthase and decreases the rate of platelet aggregation, may increase bleeding time. Feverfew, which also inhibits platelet activity, should also be avoided. 

These appear to be the only reports of ginger as a probable cause of overanticoagulation, despite the fact that prior to these Ginger Zingiber officinale ) has been sometimes listed as a herb that interacts with warfarin. on the basis that in vitro it inhibits platelet aggregation. However, this antiplatelet effect has not been demonstrated in clinical studies (which have been the subject of a review ), see also Coumarins + Herbal medicines , p.414. 

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