Gilbert’s reagent

Step 1 Conversion of an aldehyde to the corresponding terminal alkyne with Gilbert s reagent. 

The advantage of this protocol compared to Gilbert s earlier report is that the use of (PrMgCl to form the Grignard reagent allows for greater tolerance of electrophilic functional groups such as nitriles, esters, or amides. Unfortunately, lower yields are reported for the synthesis of heterocyclic... 

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