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Ghose-Crippen

Tab. 14.4 LogP calculation for quinidine via the Ghose-Crippen approach. Tab. 14.4 LogP calculation for quinidine via the Ghose-Crippen approach.
Log P is the hydrophobicity (log octanol-water partition coefficient) calculated according to the Ghose-Crippen algorithm.201 dpifA of the carboxylic acid corresponding to the W-acyloxyl substituent. [Pg.103]

Ghose-Crippen hydrophobic atomic constants -> lipophilicity descriptors... [Pg.189]

The Ghose-Crippen contribution method is based on hydrophobic atomic constants a measuring the lipophilic contributions of atoms in the molecule, each described by its neighbouring atoms [Ghose and Crippen, 1986 Ghose et al, 1988 Viswanadhan et al, 1989]. [Pg.275]

Ghose-Crippen hydrophobic atomic constants for the ith atom (or fragments) in the target molecule, and is the distance between the considered atom (or fragments) and the kth grid point. Only non-hydrogen atoms A of the molecule are usually considered. [Pg.318]

AlogP Ghose-Crippen-Viswanadhan octanol-water partition... [Pg.409]

Calculated using HyperChem version 7.5 (Hypercube, Inc., Gainesville, FL), Ghose-Crippen method. [Pg.335]

Ghose-Crippen descriptors were successfully used also to model —> molar refractivity [Ghose and Crippen, 1987] and solvation free energies [Viswanadhan, Ghose et al, 1999] by —> group contribution methods. [Pg.458]

Table L4 Ghose-Crippen atomic contributions to logP and molar refractivity (MR). Table L4 Ghose-Crippen atomic contributions to logP and molar refractivity (MR).
ALOGP, Ghose-Crippen-Viswanadhan log P AMR, Ghose-Crippen-Viswanadhan molar refractivity MW, molecular weight A, number of atoms P%, the percentage of covering. [Pg.603]

ALOGP Ghose-Crippen LOGP Template Search... [Pg.1213]

See other pages where Ghose-Crippen is mentioned: [Pg.404]    [Pg.371]    [Pg.372]    [Pg.372]    [Pg.372]    [Pg.454]    [Pg.105]    [Pg.4]    [Pg.28]    [Pg.247]    [Pg.11]    [Pg.275]    [Pg.317]    [Pg.361]    [Pg.457]    [Pg.458]    [Pg.458]    [Pg.536]    [Pg.735]    [Pg.317]    [Pg.371]    [Pg.372]   
See also in sourсe #XX -- [ Pg.361 ]

See also in sourсe #XX -- [ Pg.317 ]



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