Gerlt-Gassman/Cleland-Kreevoy proposal

So, the substance of the Gerlt-Gassman/Cleland-Kreevoy proposals appears correct, i.e., hydrogen bonding can provide much more stabilization of enolate anion intermediates under conditions of appropriate local dielectric environment than had been previously recognized by the bioorganic and biochemical communities. 

The likely importance of strong hydrogen bonding in stabilizing the dienolate anion intermediate was prominent in the formulation of both the Gerlt-Gassman and Cleland-Kreevoy proposals, even prior to the availability of high resolution... 

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