Gerhart, John

John Gerhart, University of California, Berkeley J. Paul Gilman, Celera Genomics, Rockville, Md. 

John Gerhart and Arthur Pardee found that ATCase is inhibited by CTP, the final product of the ATCase-initiated pathway. The rate of the reaction catalyzed by ATCase is fast at low concentrations of CTP but slows as CTP concentration increases (Figure 10.2). Thus, the pathway continues to make new pyrimidines until sufficient quantities of CTP have accumulated. The inhibition of ATCase by CTP is an example of feedback... 

Kirschner, Marc W., and John C. Gerhart. The Plausibility of Life Resolving Darwm s Dilemma. New Haven, Conn. Yale University Press, 2005. 

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