Gepirone hydrochloride

FIGURE 3.5 DSC traces for gepirone hydrochloride run at a range of scanning speeds. (Reproduced from Behme, R.J. et al.,./. Pharm. Sci., 74, 1041, 1985. With permission.)... 

As has been noted for DTA analysis, differential scanning calorimetry can also be used to establish the melting points of polymorphic species. For example, gepirone hydrochloride has been obtained in three polymorphic forms, which were found to melt at 180°C, 200°C, and 212°C [92]. In this work, it was shown that Forms I and II, and Forms I and III, were enantiotropic pair systems, but that Forms II and III were monotropic with respect to each other. The two polymorphs of phenylephrine oxazolidine each exhibited well-defined melting... 

Gepirone hydrochloride was found to exist in at least three polymorphic forms, whose melting points were 180°C (Form I), 212°C (Form II), and 200°C (Form El) [16]. Forms I and II, and Forms... 

Temperature dependence of the equilibrium solubilities of two polymorphic forms of gepirone hydrochloride. (The plots were adapted from data originally presented in Ref. 16.)... 

Buspirone is available as the hydrochloride salt (5 and 10 mg tablets) and is often considered to be useful for generalised anxiety disorder (GAD). Anxiolysis does not coincide with benzodiazepine-like sedation. The remaining derivatives are currently not available in most countries although tandospirone appears to he approved in Japan. The development of ipsapirone has heen discontinued and approval for gepirone for the treatment in depression is still being sought. 

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