Gentamicin sulfate cream

Fat phase Load items 2-6 in a fat-melting vessel. Heat to 70°C. Stir to melt. Hold the molten fat at 70°C while stirring at low speed in the fat-melting vessel. 

Aqueous phase Set the mixer at temperature 70°C. Heat 608.00 g of item 8 to 70°C in mixer. 

Cream preparation Transfer the molten fat at 70°C from step 1 into mixer through a stainless steel filter while mixing at speed 10 rpm, vacuum 0.6 bar. 

When the transfer is over, start the homogenizer at low speed. Homogenize for 10 minutes with recirculation. Temperature 65°-70°C. 

Stop the homogenizer, set the mixer at temperature 50°C, speed 10 rpm (manual mode), and vacuum 0.6 bar. Cool the cream to 50°C. 

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Drake TE. Letter Reaction to gentamicin sulfate cream. Arch Dermatol 1974 110(4) 638. 

Creams, ointments, and solutions containing 0.1-0.3% gentamicin sulfate have been used for the treatment of infected burns, wounds, or skin lesions and the prevention of intravenous catheter infections. Topical gentamicin is partly inactivated by purulent exudates. Ten mg can be injected subconjunctivally for treatment of ocular infections. 

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