Genotoxicity profiling

Practical Issues for Genotoxicity Profiling Vehicle, Dose, Dilution Range and Impurity... 

Computational methods allow speedy virtual research. Thus genotoxicity profiling can start before a compound has been synthesized so that chemists can avoid the synthesis of compounds with readily predictable liabilities. However because the current predictive power of computational methods derives from genotoxicity data, which as a whole tend to overpredict in vivo hazard, in silico methods should perhaps... 

Aubrecht, J., R.K. Narla, P. Ghosh, J. Stanek, and F.M. Uckun. 1999. Molecular genotoxicity profiles of apoptosis-inducing vanadocene complexes. Toxicol. Appl. Pharm. 154 228-235. 

Sobol Z, Engel ME, Rubitski E, et al. Genotoxicity profiles of common alkyl halides and esters with alkylating activity. MutatRes. 2007 633(2) 80-94. 

Darolles, C., Broggio, D., Feugier, A., et al., 2010. Different genotoxic profiles between depleted and enriched uranium. Toxicol. Lett. 192, 337-348. 

The carcinogenic potential of the profiled substance is qualitatively evaluated, when appropriate, using existing toxicokinetic, genotoxic, and carcinogenic data. ATSDR does not currently assess cancer potency or perform cancer risk assessments. Minimal risk levels (MRLs) for noncancer end points (if derived) and the end points from which they were derived are indicated and discussed. 

The carcinogenic potential of the profiled substance is qualitatively evaluated, when appropriate, using existing toxicokinetic, genotoxic, and carcinogenic data. ATSDR does not currently assess... 

Broad profiling to annotate Solubility in buffer medium micro-Ames (genotoxicity)... 

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