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Genomic approaches transcript sequencing

The second approach to sequencing RNAs, via their cDNA transcripts, is exemplified by the sequence analysis of the influenza virus haemagglutin gene (Sleigh et al., 1979). In this method a double-stranded (dsDNA) copy of the RNA genome was inserted, after digestion with nuclease Si, into the double-stranded bacterial plasmid pBR322 which was subsequently used to transform a... [Pg.216]

This chapter will discuss various experimental approaches used to select the relevant species for conduct of toxicology studies for biopharmaceuticals, as well as highlight advances made in scientific approaches and technologies to facilitate this process. Methods discussed include the traditional immunohisto-chemistry and tissue cross-reactivity studies, flow cytometry, protein sequencing, and functional in vitro assays, as well as newer approaches such as utilization of microarray databases for genomic mRNA expression data and use of transcript profiling studies as an adjunct to functional assays, to understand similarity in pharmacological responsiveness between animals and humans. [Pg.182]


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